SUPPRESSION OF RIBOSOME BIOGENESIS BY TARGETING WD REPEAT DOMAIN 12 (WDR12) INHIBITS GLIOMA STEM-LIKE CELL GROWTH

Glioma stem-like cells (GSCs) are a subset of tumor Camp Furniture cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor.Ribosome biogenesis is an essential cellular process to maintain cell growth, but its regulatory mechanism in GSCs remains largely unknown.Here, we show t

Glen S Patten1,2, Richard J Head1, Mahinda Y Abeywardena1,21CSIRO Preventative Health National Research Flagship, Adelaide, Australia; 2CSIRO Food and Nutritional Sciences, Adelaide, AustraliaBackground and aims: Chronic opioid analgesia has the debilitating side-effect of constipation in human patients.The major aims of this study were to: 1) char